I have the MH connected to my rack-mounted mioXL via DIN, works without any issues.
The reason for this is that I need to have access to the editor, which is only possible using the USB port.
You could do the same with USB, really no difference, apart from your not gonna be able to use the editor when you connect the MH to your interfaces host USB port. What MIDI interface do you use?
Just send the signal from whatever gear you want it’s midi processed to the MIDIHUB via USB and then send it back in again and use that destination as a source/input in your DAW.
I effectively use the MIDIHUB as an outboard MIDI effects processor in my setup.

