That is interesting. I read up on the FTDI mac issues, and it seems pretty par for the course for Macs; random problem that affects lots of users but not enough for them to address and fix.
Anyway, I found the FTDIKext.kext in /Library/Extensions and I found AppleUSBFTDI.kext in /System/Library/Extensions. So I assume I need to rm one of those (if not both??).
I wonder if having the WACOM installed but not active causes any issue? I unplug the WACOM tablet to make room on my desk for MIDI controllers. I’ll investigate removing the driver for it, it’s not a critical big deal to rm and reinstall if I have to.
I have a RaPi but have never connected it to the Mac. Most USB devices are plug and play system compliant so no drivers needed. The WACOM is about the only USB thing I have to install drivers for. There is the Behringer Neutron software, and perhaps AKAI MPX16. Thinking about it, all the music licensing apps; eLicenser, Arturia MCC, Native Instruments Service Center, etc etc. They all connect some software with some hardware.
I did find this article How to Fix FTDI Driver Issue on Mac and macOS - Alorium Technology and this discussion USB driver for serial comm (FTDI) - Apple Community that I’m following down the rabbit hole.
I shall report back.
Thanks again for your support.